Date:
Monday, May 13, 2024, 1:00pm to 2:00pm
Jun Yan (Adamson Lab) Princeton University
Improving prime editing with an endogenous small RNA-binding protein
Nature 2024
Past Seminar Schedule
2024
Apr
22
Victor Tieu and David Fiflis
Date:
Monday, April 22, 2024, 1:00pm to 2:00pm
Victor Tieu (Qi Lab and Mackall Lab). Stanford Universiry
Cell 2024
David Fiflis (Asokan Lab). Duke University
Repurposing CRISPR-Cas13 systems for robust mRNA trans-splicing
Nature Communications 2024
2024
Apr
08
Julian Geilenkeuser & Dong-Jiunn Jeffery Truong and Briana Van Treeck
Date:
Monday, April 8, 2024, 1:00pm to 2:00pm
Julian Geilenkeuser and Dong-Jiunn Jeffery Truong (Westmeyer Lab), Technical University of Munich
Exonuclease-enhanced prime editors
Nature Methods 2024
Briana Van Treeck (Collins Lab), University of California at Berkeley
Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci
Nature Biotechnology 2024
2024
Apr
01
Han Altae-Tran & Soumya Kannan and Ryan McNulty
Date:
Monday, April 1, 2024, 1:00pm to 2:00pm
Han Altae-Tran & Soumya Kannan (Zhang Lab), Broad Institute and MIT
Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering
Science 2024
Ryan McNulty (Adamson Lab), Princeton University
Efficient prime editing in two-cell mouse embryos using PEmbryo
Nature Biotechnology 2024
2024
Mar
25
Matt Durrant, Nicholas Perry and Emma Huang
Date:
Monday, March 25, 2024, 1:10pm to 2:00pm
Matt Durrant and Nicholas Perry (Hsu Lab), Arc Institute
Bridge RNAs direct modular and programmable recombination of target and donor DNA
Biorxiv 2024
Emma Huang (Feilong Meng Lab), University of Chinese Academy of Sciences
C-to-G editing generates double-strand breaks causing deletion, transversion and translocation
Nature Cell Biology 2024
Recording: https://harvard.zoom.us/rec/play/cC_qnlqSQClsNmCZBdXXigB2vdiVPTkc3Dg01Ow...
2024
Mar
11
Liliya Mukhametzyanova, Sarah Camara-Wilpert, and David Mayo-Muñoz
Date:
Monday, March 11, 2024, 1:00pm to 2:00pm
Liliya Mukhametzyanova (Buchholz Lab), Technical University Dresden
Activation of recombinases at specific DNA loci by zinc-finger domain insertions
Nature Biotechnology 2024
Sarah Camara-Wilpert and David Mayo-Muñoz (Redondo Lab and Fineran Lab), University of Copenhagen and University of Otago
Bacteriophages suppress CRISPR–Cas immunity using RNA-based anti-CRISPRs
Nature 2023
2024
Mar
04
Ralf Schmidt, Carl Ward, and Zi-Xian Liu
Date:
Monday, March 4, 2024, 1:00pm to 2:00pm
Ralf Schmidt and Carl Ward (Marson Lab), Gladstone-UCSF Institute of Genomic Immunology
Base-editing mutagenesis maps alleles to tune human T cell functions
Nature 2023
Zi-Xian Liu (Liu Lab) Tsinghua University
Hydrolytic endonucleolytic ribozyme (HYER) is programmable for sequence-specific DNA cleavage
Science 2024
2024
Feb
26
Weimin Zhang, Cian Schmitt-Ulms, and Alisan Kayabolen
Date:
Monday, February 26, 2024, 1:00pm to 2:00pm
Weimin Zhang (Boeke Lab), NYU Langone Health
Mouse genome rewriting and tailoring of three important disease loci
Nature 2023
Cian Schmitt-Ulms and Alisan Kayabolen (Abudayyeh-Gootenberg Lab), Broad Institute of MIT and Harvard
Programmable RNA writing with trans-splicing
Biorxiv 2024
2023
Nov
30
Symposium at Harvard Medical School (In-person & Virtual)
Date:
Thursday, November 30, 2023, 10:00am to 5:00pm
2023
Nov
27
BREAK
Date:
Monday, November 27, 2023, 1:00pm to 2:00pm
2023
Nov
20
Nicolas Mathis & Elijah Mena
Date:
Monday, November 20, 2023, 1:00pm to 2:00pm
Nicolas Mathis (Schwank Lab), University of Zurich
bioRxiv 2023
Elijah Mena (Elledge lab), Harvard Medical School
Defining E3 ligase–substrate relationships through multiplex CRISPR screening
Nature Cell Biology 2023
2023
Nov
13
Connor Tou & Barun Mahata
Date:
Monday, November 13, 2023, 1:00pm to 2:00pm
Connor Tou and Joana Ferreira da Silva (Kleinstiver Lab), Mass General Hospital (MGH), MIT and Harvard Medical School (HMS)
Click editing enables programmable genome writing using DNA polymerases and HUH endonucleases
bioRvix 2023
Barun Mahata (Hilton lab), Rice University.
Nature Methods 2023
Recording: https://harvard.zoom.us/rec/share/_aE2qk5exvp0PHmK_sZqH8szkq1rM_PsIPXPg_...
2023
Nov
06
BREAK
Date:
Monday, November 6, 2023, 1:00pm to 2:00pm
2023
Oct
30
Laura Breda, Tyler Papp, Michael Triebwasser and António J. Santinha
Date:
Monday, October 30, 2023, 1:00pm to 2:00pm
Laura Breda, Tyler Papp, and Michael Triebwasser (Hamideh Parhiz Lab), Perelman School of Medicine, University of Pennsylvania, and Children's Hospital of Philadelphia
In vivo hematopoietic stem cell modification by mRNA delivery
Science 2023
Antonio Santinha (Platt Lab), ETH Zurich
Transcriptional linkage analysis with in vivo AAV-Perturb-seq
Nature 2023
Recording: https://harvard.zoom.us/rec/share/4s_CHtPkdTFGARQipXPTKvM_ecSX23Qz5MtO5q...
2023
Oct
23
Lukas Schmidheini and Chris Hsiung
Date:
Monday, October 23, 2023, 1:00pm to 2:00pm
Lukas Schmidheini (Schwank Lab), University of Zurich
Continuous directed evolution of a compact CjCas9 variant with broad PAM compatibility
Nature Chemical Biology 2023
Chris Hsiung (Gilbert Lab), Arc Institute
bioRxiv 2023
2023
Oct
16
Dana Foss and Joseph Muldoon, and José L. McFaline-Figueroa
Date:
Monday, October 16, 2023, 1:00pm to 2:00pm
Dana Foss and Joseph Muldoon (Wilson Lab) University of California, Berkeley; (Eyquem Lab) University of California, San Francisco;
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes
Nature Biomedical Engineering 2023
José L. McFaline-Figueroa (McFaline-Figueroa Lab) Columbia University
Biorxiv 2023
2023
Oct
09
HOLIDAY
Date:
Monday, October 9, 2023, 1:00pm to 2:00pm
2023
Oct
02
Goosang Yu and Martina Fiumara
Date:
Monday, October 2, 2023, 1:00pm to 2:00pm
Goosang Yu, (Hyongbum Henry Kim Lab), Yonsei University College of Medicine, Seoul 03722, Republic of Korea
Prediction of efficiencies for diverse prime editing systems in multiple cell types
Cell 2023
Martina Fiumara (Luigi Naldini Lab), San Raffaele Telethon Institute for Gene Therapy, Milan, Italy
Genotoxic effects of base and prime editing in human hematopoietic stem cells
Nature Biotechnology 2023
2023
Sep
25
Stephan Riesenberg and Xiaoyi Li
Date:
Monday, September 25, 2023, 1:00pm to 2:00pm
Stephan Riesenberg, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
Efficient high-precision homology-directed repair-dependent genome editing by HDRobust
Nature Methods 2023
Xiaoyi Li (Shendure Lab), University of Washington, Seattle, WA, USA
Chromatin context-dependent regulation and epigenetic manipulation of prime editing
bioRxiv 2023
2023
Sep
18
Hongyuan Fei and Xingjie Ren & Han Yang
Date:
Monday, September 18, 2023, 1:00pm to 2:00pm
Hongyuan Fei (Kevin Zhao, Qi Biodesign), (Gao Lab) University of Chinese Academy of Sciences, Beijing, China
Discovery of deaminase functions by structure-based protein clustering
Cell 2023
Xingjie Ren and Han Yang (Shen Lab); University of California, San Francisco
High throughput PRIME editing screens identify functional DNA variants in the human genome
bioRxiv 2023
2023
May
22
George Lampe & Rebeca King and Florence Chardon
Date:
Monday, May 22, 2023, 1:00pm to 2:00pm
George Lampe & Rebeca King (Sternberg Lab). Columbia University, New York
Nature Biotechnology 2023
Florence Chardon (Shendure Lab). University of Washington, Seattle,
Multiplex, single-cell CRISPRa screening for cell type specific regulatory elements
bioRxiv 2023
2023
May
15
Break - No Seminar
Date:
Monday, May 15, 2023, 1:00pm to 2:00pm
2023
May
08
Kristin Knouse and Jaesuk Lee
Date:
Monday, May 8, 2023, 1:00pm to 2:00pm
Kristin Knouse, Massachusetts Institute of Technology (MIT).
Genome-scale CRISPR screening in a single mouse liver
Cell Genomics 2022
Jaesuk Lee (Jin-Soo Kim Lab) Center for Genome Engineering, Institute for Basic Science, Daejeon, Republic of Korea.
Prime editing with genuine Cas9 nickases minimizes unwanted indels
Nature Communications 2023
2023
May
01
Michael Wheeler and Connor Tsuchida
Date:
Monday, May 1, 2023, 1:00pm to 2:00pm
Michael Wheeler, Brigham and Women's Hospital, Harvard Medical School, The Broad Institute
Droplet-based forward genetic screening of astrocyte–microglia cross-talk
Science 2023
Connor Tsuchida (Doudna Lab), University of California, Berkeley. Innovative Genomics Institute
Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells
bioRxiv 2023
2023
Apr
24
Jing Zeng, Linda Yingqi Lin, Manuel Tognon and Qianxin Wu
Date:
Monday, April 24, 2023, 1:00pm to 2:00pm
Jing Zeng, Linda Yingqi Lin (Bauer Lab), Manuel Tognon (Giugno Lab). Boston Children's Hospital, Harvard Medical School, University Verona
Human genetic diversity alters off-target outcomes of therapeutic gene editing
Nature Genetics 2023
Qianxin Wu, Wellcome Sanger Institute
Molecular Cell 2023
2023
Apr
17
Break - No Seminar
Date:
Monday, April 17, 2023, 1:00pm to 2:00pm
2023
Apr
10
Jonas Koeppel & Juliane Weller & Elin Madli Peets and Osama Abdin
Date:
Monday, April 10, 2023, 1:00pm to 2:00pm
Jonas Koeppel & Juliane Weller & Elin Madli Peets (Parts Group). Wellcome Sanger Institute, UK
Nature Biotechnology (2023)
Osama Abdin (Philip M. Kim Lab). University of Toronto, Canada
A universal deep-learning model for zinc finger design enables transcription factor reprogramming
Nature Biotechnology (2023)
2023
Apr
03
Erman Karasu and Shota Nakade
Date:
Monday, April 3, 2023, 1:00pm to 2:00pm
Erman Karasu (Corn Lab). ETH Zurich
TREX1 restricts CRISPR-Cas9 genome editing in human cells
bioRxiv 2023
Shota Nakade (Timothy Lu Lab). Massachusetts Institute of Technology (MIT)
Frame Editors for Precise, Template-Free Frameshift
bioRxiv 2022
2023
Mar
27
Lucie Guo and Hannah Ghasemi
Date:
Monday, March 27, 2023, 1:00pm to 2:00pm
Lucie Guo, Lei (Stanley) Qi Lab. Stanford University
Multiplexed genome regulation in vivo with hyper-efficient Cas12a
Nature Cell Biology 2022
Hannah Ghasemi (Richardson Lab). UC Santa Barbara
Interstrand crosslinking of homologous repair template DNA enhances gene editing in human cells
Nature Biotechnology 2023
2023
Mar
20
Break
Date:
Monday, March 20, 2023, 1:00pm to 2:00pm
2023
Mar
13
David Colognori and Huawei Tong
Date:
Monday, March 13, 2023, 1:00pm to 2:00pm
David Colognori (Doudna Lab). University of California, Berkeley.
Precise transcript targeting by CRISPR-Csm complexes
Nature Biotechnology 2023
Huawei Tong (Yang Lab). HuiGene Therapeutics Co. Ltd, China
High-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects
Nature Biotechnology 2022